INVESTIGATION OF PARACETAMOL RELEASE FROM THYME OIL- CONTAINING ORGANO-HYDROGELS AT DIFFERENT PHS AND THE EFFECT OF KINETIC MODELS

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ABSTRACT Herbal and herbal oils obtained from plants are used in many areas due to their natural, cheap,easy-to-process, biodegradable, corrosive, and non-toxic properties. The use of newpolymeric materials, especially obtained from herbal and herbal oil which maintain theirstructural properties for a longer period, as controlled drug release support materials in themedical field is among the most popular topics of recent times. This study focused on thesynthesis of new organo-hydrogels based on thyme oil and their use as drug-release supportmaterials. In the synthesis of organo-hydrogels (poly (AG-co-TO)), cross-linking of agar (A),glycerol (G), and thyme oil (TO) was achieved in an emulsion environment by free radicalpolymerization technique. Glutaraldehyde (GA) and methylenebisacrylamide (MBA) wereused as cross-linkers. In poly (AG-co-TO) based organo-hydrogel synthesis, while theamounts of A, G, GA, and MBA were kept constant, TO was added to the polymerizationmedium in three different amounts. At the same time, paracetamol was chosen as the drug andwas added to the polymerization mixture to ensure its physical or chemical binding to theorgano-hydrogel structure. Finally, the release behavior and release kinetics of the drugparacetamol from the synthesized drug-loaded organo-hydrogel structure in different pHenvironments were examined. As a result of the release experiments, it was found that thehighest release amount was 89.83 for p(AG-co-TO)3 at pH 7.4 after 4320 minutes. It wasdetermined that the drug release efficiency of paracetamol-loaded organo-hydrogels increasedas the amount of TO added to the structure increased. Considering the results obtained, it isthought that the use of thyme oil-based organo-hydrogels as drug-release support materialswill make a significant contribution to the literature. Keyword: Thyme oil, Organo-hydrogel, Paracetamol, Release, Drug kinetics