Article detail · 2021
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Journal
Cell Reports- Year
- 2021
- Type
- article
Data source split
- YÖKSİS venue Cell Reports
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We have characterized motile ciliated cells within the zebrafish brain ventricles. We show that the ventricles undergo restructuring through development, involving a transition from mono- to multiciliated cells (MCCs) driven by gmnc. MCCs co-exist with monociliated cells and generate directional flow patterns. These ciliated cells have different developmental origins and are genetically heterogenous with respect to expression of the Foxj1 family of ciliary master regulators. Finally, we show that cilia loss from the tela choroida and choroid plexus or global perturbation of multiciliation does not affect overall brain or spine morphogenesis but results in enlarged ventricles. Our findings establish that motile ciliated cells are generated by complementary and sequential transcriptional programs to support ventricular development.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
87 citations
OpenAlex cited_by_count (cache / database)
9 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation 2024
- Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain 2025
- Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish 2024
- Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors 2025
- Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo 2022
- Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors 2024
- Loss of cilia after neurulation impacts brain development and neuronal activity in larval zebrafish 2023
- Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons 2023
- Cilia-mediated cerebrospinal fluid flow modulates neuronal and astroglial activity in the zebrafish larval brain 2024