Article detail · 2025
New Mannich-type arylidenerhodanines as potent inhibitors of AChE and BChE: synthesis, biological evaluation, cytotoxicity and molecular modeling
- Year
- 2025
- Type
- article
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- YÖKSİS YÖKSİS article record
- YÖKSİS venue RSC Advances
- Catalog match (ISSN) RSC Advances
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
for BChE. Moreover, the 250 ns molecular dynamics simulations gave a confirmation of the structural stability and the prolonged existence of the key interactions in the enzyme active sites during the entire time. The findings of this research emphasize compounds 6 and 11 as potential candidates for the creation of strong cholinesterase inhibitors for the treatment of Alzheimer's disease, thus encouraging additional studies.
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22 citations
OpenAlex cited_by_count (cache / database)
11 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybrids 2026
- Evaluation of pyrimidine-based compounds as AChE and BChE inhibitors: in vitro inhibition, molecular modeling, and statistical evaluation 2026
- Novel Approach to Synthesis of Diaryl Tacrine Derivatives and Evaluation of Their Inhibitory Effects on Cholinesterase Enzymes 2026
- Novel Approach to Synthesis of Diaryl Tacrine Derivatives and Evaluation of Their Inhibitory Effects on Cholinesterase Enzymes 2026
- Novel Approach to Synthesis of Diaryl Tacrine Derivatives and Evaluation of Their Inhibitory Effects on Cholinesterase Enzymes 2026
- Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole‐Based Thiosemicarbazones as Potential AChE and CA I‐II Inhibitors 2026
- Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole‐Based Thiosemicarbazones as Potential AChE and CA I‐II Inhibitors 2026
- Development of novel diaryl ether–phenolic Mannich Base derivatives with potent cholinesterase inhibition and low neuronal toxicity 2026
- Development of novel diaryl ether–phenolic Mannich Base derivatives with potent cholinesterase inhibition and low neuronal toxicity 2026
- Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole‐Based Thiosemicarbazones as Potential AChE and CA I‐II Inhibitors 2026