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Article detail · 2008

Establishing the Use of Melatonin as an Adjuvant Therapeutic Against Paraquat-Induced Lung Toxicity in Rats

Journal

Experimental Biology and Medicine
OpenAlex SJR Q1 JCR Q2 Citations 28 Percentile 82.6% FWCI 1.49
Year
2008
DOI
10.3181/0802-rm-65
Type
article

Data source split

  • YÖKSİS venue Experimental Biology and Medicine
  • OpenAlex OpenAlex enrichment (abstract, citations, topics)

OpenAlex record

Abstract

OpenAlex · English

It is well known that the intake of paraquat (PQ) causes severe tissue injury leading to numerous fatalities. Considering that the main target for PQ toxicity is the lung and involves the production of reactive oxygen and nitrogen species, transcription factors and inflammatory cytokines, it may be hypothesized that the combination of a potent antiinflammatory and antioxidant agent may counteract more of PQ's effects than an antiinflammatory agent alone. For this purpose, combination of dexamethasone (Dex) and melatonin (Mel) was compared with Dex alone. A total of 40 male Wistar albino rats were divided into four groups as control, PQ, Dex only, and Dex plus Mel. The animals were given intraperitoneally a toxic dose of 19 mg/kg PQ dissolved in 1 ml saline. Control animals were injected with the same amount of saline only. A dose of 1 mg/kg Dex was administered 2 hrs after PQ administration. In the combination treatment group, 20 mg/kg Mel was given with Dex. All drugs were given every 12 hrs for a total of six doses. Five animals in PQ group and three animals in Dex only group died by the end of the study. No deaths occurred in the Dex+Mel group. Dex exerted improvements in several oxidative and antioxidative parameters. However, combination treatment provided beneficial effects against PQ toxicity far greater than Dex alone. This difference was also apparent when tissues were histologically compared. In conclusion, Mel exhibited strong additive beneficial effects with Dex and can be considered as a safe treatment modality against PQ toxicity.

Topics

Citations

OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.

28 citations

OpenAlex cited_by_count (cache / database)

14 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).

  1. Role of melatonin in metabolic regulation 2009 Citations 147 · OpenAlex
  2. Gene regulation by melatonin linked to epigenetic phenomena 2012 Citations 124 · OpenAlex
  3. The relation between oxidative stress inflammation and neopterin in the paraquat induced lung toxicity 2015 Citations 72 · OpenAlex
  4. The relation between oxidative stress inflammation and neopterin in the paraquat induced lung toxicity 2015 Citations 72 · OpenAlex
  5. The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity 2015 Citations 72 · OpenAlex
  6. The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity 2014 Citations 72 · OpenAlex
  7. Effect of hyperbaric oxygen and ozone preconditioning on oxidative nitrosative stress induced by tourniquet ischemia reperfusion in rat skeletal muscle 2010 Citations 41 · OpenAlex
  8. Effect of hyperbaric oxygen and ozone preconditioning on oxidative nitrosative stress induced by tourniquet ischemia reperfusion in rat skeletal muscle 2010 Citations 41 · OpenAlex
  9. Effect of hyperbaric oxygen and ozone preconditioning on oxidative nitrosative stress induced by tourniquet ischemia reperfusion in rat skeletal muscle 2010 Citations 41 · OpenAlex
  10. Ozone therapy ameliorates paraquat induced lung injury in rats 2014 Citations 11 · OpenAlex

Authors

No author information.