Article detail · 1993
Retinoblastoma and p 53 tumor suppressor genes in human hepatoma cell lines
Journal
The FASEB Journal- Year
- 1993
- Type
- article
Data source split
- YÖKSİS venue The FASEB Journal
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
We analyzed the status of retinoblastoma and p53 genes in 10 human hepatoma cell lines. Polyclonal anti‐peptide antibodies generated against peptides homologous to COOH‐terminal and leucine‐zipper domains of the retinoblastoma protein allowed us to identify two cell lines (Hep 3B and FOCUS) with abnormal expression. The same cell lines have both lacked p53 expression. In contrast to the retinoblastoma gene, the expression of the p53 gene was abnormal in six additional cell lines. Indeed, only the Hep G2 hepatoblastoma cell line (and its derivative Hep G2/2215) appeared to have normal p53 and retinoblastoma gene expression. Our studies indicate that p53 abnormalities are common but retinoblastoma gene aberrations are rare in human hepatoma cell lines.—Puisieux, A., Galvin, K., Troalen, F., Bressac, B., Marcais, C., Galun, E., Ponchel, F., Yakicier, C., Ji, J., Ozturk, M. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J. 7: 1407‐1413; 1993.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
126 citations
OpenAlex cited_by_count (cache / database)
9 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Identification of BTG2 an antiproliferative p53 dependent component of the DNA damage cellular response pathway 1996
- Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis. 1994
- Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation 2011
- Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells 2001
- p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus. 1995
- Somatic mutations of von Hippel‐Lindau (VHL) tumor‐suppressor gene in european kidney cancers 1995
- p53 but not p16INK4a induces growth arrest in retinoblastoma deficient hepatocellular carcinoma cells 2000
- Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells 2025
- ~53 but not ~16~~~ induces growth arrest in retinoblastomadeficient hepatocelhilar carcinoma cells 2000