Article detail · 2013
The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia Reperfusion
- Year
- 2013
- Type
- article
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- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Endourology
- Catalog match (ISSN) Journal of Endourology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
PURPOSE: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. METHODS: Thirty-two rats were randomly divided into a control group and three I/R groups (1-hour ischemia followed by 23-hour reperfusion). Three I/R groups were treated by apocynin (20 mg/kg, i.p.) at two different time points (before ischemia and during ischemia). The histopathological findings, including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPX), reduced glutathione (GSH), myeloperoxidase (MPO), blood urea nitrogen (BUN), and serum creatinine (Cr) levels, were determined. RESULTS: Kidney tissue MDA and MPO, and serum BUN and Cr levels were found to be significantly higher in the I/R group, but there was no statistically significant difference in the levels of SOD, CAT, GPX, and GSH between the I/R and the control groups. Although apocynin significantly reduced MDA and MPO in group 3 and increased GPX in both treatment groups when compared to the I/R group, the elevated BUN and Cr levels were significantly reduced in treatment groups. Renal I/R injury also induced extensive tubular necrosis, glomerular damage, and apoptosis in the histological evaluation. Apocynin, especially when used during ischemia, ameliorated these histological damages in different amounts in treatment groups. CONCLUSION: The beneficial effects of apocynin on renal I/R injury were evaluated for the first time.
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Citations
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57 citations
OpenAlex cited_by_count (cache / database)
33 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- The Protective Effect of Apocynin on Testicular Ischemia Reperfusion Injury 2015
- The Protective Effect of Apocynin on Testicular Ischemia Reperfusion Injury 2015
- Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats 2015
- Protective Effects of Apocynin on Cisplatin induced Hepatotoxicity in Rats 2015
- Protective Effects of Apocynin on Cisplatin induced Hepatotoxicity in Rats 2015
- Apocynin attenuates testicular ischemia–reperfusion injury in rats 2014
- Protective and Therapeutic Effect of Apocynin on Bleomycin-Induced Lung Fibrosis in Rats 2015
- Protective and Therapeutic Effect of Apocynin on Bleomycin Induced Lung Fibrosis in Rats 2015
- Inhibition of NADPH oxidase by apocynin promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress in rats 2017
- Protective effect of sitagliptin against renal ischemia reperfusion injury in rats 2015