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Article detail · 2008

Comparison of the Efficacy of Tigecycline and Teicoplanin in an Experimental Methicillin-ResistantStaphylococcus aureusOsteomyelitis Model

Journal

Journal of Chemotherapy
OpenAlex SJR Q2 JCR Q4 Citations 33 Percentile 78.6% FWCI 1.29
Year
2008
DOI
10.1179/joc.2008.20.1.53
Type
article

Data source split

  • YÖKSİS venue Journal of Chemotherapy
  • OpenAlex OpenAlex enrichment (abstract, citations, topics)

OpenAlex record

Abstract

OpenAlex · English

We evaluated the efficacy of tigecycline and teicoplanin in a rat model of MRSA osteomyelitis. Osteomyelitis was induced with an intramedullary injection of 10(8 )colony-forming units (cfu) of MRSA. After osteomyelitis formation was confirmed on Day 14, infected rats were randomly divided into three groups: tigecycline (n=13), teicoplanin (n=13), and no-treatment control (n=14). A 28-day antibiotic therapy with a subcutaneous injection of tigecycline (14 mg/kg twice daily) or intramuscular administration of teicoplanin (20 mg/kg daily) was administered. Rats were then sacrificed, and the tibias were harvested. The bones were weighed and then cultured. Our results indicated that bacterial growth was significantly reduced in teicoplanin and tigecycline groups, compared to the control group (p=0.019 and p=0.006, respectively). However, no difference was detected between the two antibiotic groups (p=1.000). No bacterial growth was detected in 7 out of 13 and 9 out of 13 specimens of the teicoplanin and tigecycline treated groups, respectively. Although this result was numerically in favor of tigecycline, the difference was not statistically significant (p=0.427). In conclusion, tigecycline, a novel antibiotic, appears as an effective alternative to teicoplanin in the treatment of osteomyelitis caused by MRSA.

Topics

Citations

OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.

33 citations

OpenAlex cited_by_count (cache / database)

9 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).

  1. Successful use of tigecycline for treatment of culture negative pyogenic vertebral osteomyelitis 2015 Citations 17 · OpenAlex
  2. Local treatment of chronic osteomyelitis with surgical debridement and tigecycline impregnated calcium hydroxyapatite an experimental study 2012 Citations 17 · OpenAlex
  3. Local treatment of chronic osteomyelitis with surgical debridement and tigecycline impregnated calcium hydroxyapatite an experimental study 2012 Citations 17 · OpenAlex
  4. Tigecycline in the management of post neurosurgical spondylodiscitis a review of eight cases 2014 Citations 14 · OpenAlex
  5. Tigecycline in the management of post neurosurgical spondylodiscitis a review of eight cases 2014 Citations 14 · OpenAlex
  6. Tigecycline in the management of post neurosurgical spondylodiscitis a review of eight cases 2014 Citations 14 · OpenAlex
  7. Tigecycline in the management of post neurosurgical spondylodiscitis a review of eight cases 2014 Citations 14 · OpenAlex
  8. Tigecycline-based prolonged salvage therapy in patients presenting with complex bone and joint infection 2018 Citations 6 · OpenAlex
  9. Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain 2025 Citations 5 · OpenAlex

Authors

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