Article detail · 2009
Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes
Journal
Clinical and Experimental Dermatology- Year
- 2009
- Type
- article
Data source split
- YÖKSİS venue Clinical and Experimental Dermatology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: Diabetes is a condition known even in its early stages to impair the normal course of wound healing, thus leading to chronic wounds. The role of insulin in the regulation of energy metabolism, protein synthesis, cell differentiation and growth suggests that this hormone could also play an essential role in regulation of wound healing. AIM: To determine the effects of topical insulin administration on wound healing in rats with or without acute diabetes. METHODS: This study was conducted using four groups of male Sprague-Dawley rats: (i) nondiabetic rats receiving topical insulin (n = 7), (ii) nondiabetic rats receiving topical sterile water (n = 7), (iii) diabetic rats receiving topical insulin (n = 7) and (iv) diabetic rats receiving topical sterile water (n = 7). Wound healing was assessed by wound contraction rate, complete epithelialization time and histological results. RESULTS: Topical insulin enhanced wound healing by shortening the time needed for complete epithelialization in both the nondiabetic and acute diabetic groups. The histological observations supported the planimetric results in both groups. CONCLUSIONS: This study revealed that topical insulin application to cutaneous wounds accelerates wound healing in rats with or without acute diabetes.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
78 citations
OpenAlex cited_by_count (cache / database)
13 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Ethanol extract of Cotinus coggygria leaves accelerates wound healing process in diabetic rats 2016
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- Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing 2019
- A new dressing material in diabetic wounds: Wound healing activity of oleuropein-rich olive leaf extract in diabetic rats 2016
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- Effects of topical neutral protamine Hagedorn insulin on corneal wound healing: an experimental study in rabbits 2025
- Effects of topical neutral protamine Hagedorn insulin on corneal wound healing: an experimental study in rabbits 2025