Article detail · 2015
Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia
- Year
- 2015
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Investigative Medicine
- Catalog match (ISSN) Journal of Investigative Medicine
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance. METHODS: Subjects with asymptomatic hyperuricemia (n = 73) were prospectively placed on allopurinol (n = 40) or control (n = 33) for 3 months. An additional control group consisted of 48 normouricemic subjects. Serum uric acid, fasting glucose, fasting insulin, HOMA-IR (homeostatic model assessment of insulin resistance), and high-sensitivity C-reactive protein were measured at baseline and at 3 months. RESULTS: Allopurinol-treated subjects showed a reduction in serum uric acid in association with improvement in fasting blood glucose, fasting insulin, and HOMA-IR index, as well as a reduction in serum high-sensitivity C-reactive protein. The number of subjects with impaired fasting glucose significantly decreased in the allopurinol group at 3 months compared with baseline (n = 8 [20%] vs n = 30 [75%], 3 months vs baseline, P < 0.001). In the hyperuricemic control group, only glucose decreased significantly and, in the normouricemic control, no end point changed. CONCLUSIONS: Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia. Larger clinical trials are recommended to determine if lowering uric acid can help prevent type 2 diabetes.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
182 citations
OpenAlex cited_by_count (cache / database)
11 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Uric Acid is a Useful Tool to Predict Contrast-Induced Nephropathy 2017
- Uric Acid is a Useful Tool to Predict Contrast-Induced Nephropathy 2017
- The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review 2022
- Therapeutic implications of shared mechanisms in non-alcoholic fatty liver disease and chronic kidney disease 2020
- The role of uric acid in mineral bone disorders in chronic kidney disease 2019
- Association of uric acid with metabolic parameters and obesity 2020
- Machine Learning Insights Into Uric Acid Elevation With Thiazide Therapy Commencement and Intensification 2023
- A Study on The Early Metabolic Effects of Salt and Fructose Consumption: The Protective Role of Water 2024
- Machine Learning Insights into Uric Acid Elevation with Thiazide Therapy Commencement and Intensification 2023
- Ultrasonographic Evaluation of Femoral Cartilage Thickness in Participants with Asymptomatic Hyperuricemia: A Case-Control Study 2023