Article detail · 1996 · article
Synthesis and anticonvulsant activity of new 3-[(2-furyl)carbonyl]amino-4-thiazolidinone and 2-[(2-furyl)carbonyl]hydrazono-4-thiazoline derivatives.
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Abstract
A series of new 2-aryl-3-[(2-furyl)carbonyl]amino-5-nonsubstituted/methyl-4-thi azolidinones (3) and 2-[(2-furyl)carbonyl]hydrazono-3-alkyl-4-aryl-4-thiazolines (5) was synthesized and evaluated for anticonvulsant activity against pentylenetetrazole induced seizures. Preliminary results indicated that potency was sensitive to substituents at the 2 and 5 positions of the 4-thiazolidinone and 3 and 4 positions of the 4-thiazoline rings. Among 3,2-(phenyl)/ (4-fluorophenyl)-3-[(2-furyl)carbonyl]amino-5-methyl-4-thiazolidinone s (3e and 3f) and among 5, 2-[(2-furyl)carbonyl]hydrazono-3-allyl-4-(4-bromophenyl)-4-thiazol ine (5e), showed the highest protection (40%).
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34citationsOpenAlex · cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- 2002 Synthesis characterisation and biological activity of novel4 thiazolidinones 1 3 4 oxadiazoles and some related compoundsCitations 402 · OpenAlex
- 2002 Synthesis characterisation and biological activity of novel 4 thiazolidinones 1 3 4 oxadiazoles and some related compoundsCitations 402 · OpenAlex
- 2006 Synthesis and antimycobacterial activity of new 2 hydroxy N 3 oxo 1 thia 4 azaspiro 4 4 non 4 yl 3 oxo 1 thia 4 azaspiro 4 5 dec 4 yl 2 2 diphenylacetamide derivativesCitations 24 · OpenAlex
- 2010 Synthesis and antimicrobial evaluation of new 3 alkyl aryl 2 diphenyl hydroxy acetyl hydrazono 5 methyl 4 thiazolidinonesCitations 9 · OpenAlex
- 2010 Synthesis and antimicrobial evaluation of new 3 alkyl aryl 2 diphenyl hydroxy acetyl hydrazono 5 methyl 4 thiazolidinonesCitations 9 · OpenAlex
- 2015 Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazideCitations 3 · OpenAlex
- 1997 ChemInform Abstract: Synthesis and Anticonvulsant Activity of New 3‐((2‐Furyl)carbonyl) amino‐4‐thiazolidinone and 2‐((2‐Furyl)carbonyl)hydrazono‐4‐thiazoline Derivatives.Citations 1 · OpenAlex
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