Article detail · 2012
Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus
Journal
Medicinal Chemistry Research- Year
- 2012
- Type
- article
Data source split
- YÖKSİS venue Medicinal Chemistry Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide ( 4 ) was obtained starting from 6-morpholin-4-ylpyridin-3-amine ( 2 ) via the formation of ester ( 3 ) and then converted to the corresponding Schiff bases ( 5, 6 ) with the reaction with aromatic aldehydes. The carbothioamide ( 9 ), obtained from the reaction of hydrazide with phenylisothiocyanate, was converted to the corresponding 1,2,4-triazole ( 11 ) and 1,3,4-thiadiazole ( 12 ) derivatives by the treatment with NaOH or H 2 SO 4 , respectively. The cyclocondenzation of 9 with 4-chlorophenacyl bromide or ethyl bromoacetate produced the corresponding 1,3-thiazole ( 10 ) or 1,3-thiazolidine derivatives ( 13 ), respectively. Antimicrobial and antiurease activities of newly synthesized compounds were investigated. Some of them were found to be active on M. smegmatis , and they displayed activity toward C. albicans and S. cerevisiae in high concentration. Compound 10 proved to be the most potent showing an enzyme inhibition activity with an IC 50 = 2.37 ± 0.19 μM.
Topics
Citations
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61 citations
OpenAlex cited_by_count (cache / database)
15 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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