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Article detail · 2018

Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-naproxen as anticancer agents

Journal

Marmara Pharmaceutical Journal

ISSN 2630-6344

The ISSN points to another catalog journal; the name is from the YÖKSİS record.

YÖKSİS OpenAlex Open access · diamond SJR Q3 TR Index Citations 33 Percentile 72.8% FWCI 1.06
Year
2018
DOI
10.12991/jrp.2018.98
Type
article

Data source split

  • YÖKSİS YÖKSİS article record
  • YÖKSİS venue Marmara Pharmaceutical Journal
  • Catalog match (ISSN) Journal of Research in Pharmacy
  • OpenAlex OpenAlex enrichment (abstract, citations, topics)

OpenAlex record

Abstract

OpenAlex · English

A novel series of new naproxen derivatives (S)-ethyl{[4-(4-fluorophenyl)-5-[(1-(6-methoxynaphtalen-2yl)ethyl)]-4H-1,2,4-triazole-3-yl]sulphanyl}acetate (5), (S)-2-({5-[1-(6-methoxynaphtalen-1-yl)ethyl]-4-fluorophenyl-4H-1,2,4-triazole-3-yl}sulphanyl)acetohydrazide (6), 2-{[5-[1-(6-methoxynaphtalen-2-yl)ethyl]-4-(4-fluorophenyl)-4H-1,2,4triazole-3-yl]sulphanyl}-N'-[(substituted)methylidene]acetohydrazides (7a-m) were synthesized, in this study.The structures of compounds 5, 6 and 7a-m were defined by spectral ( 1 H-NMR, 13 C-NMR, HR-MS and FT-IR) methods and their purity was proven by elemental analysis, thin layer chromatography and high pressure liquid chromatography.These compounds were evaluated for in vitro anticancer activity by using MTS method against PC-3 and DU-143 (androgen-independent human prostate cancer cell lines) and LNCaP (androgen-sensitive human prostate adenocarcinoma) prostate cancer cell lines.Cisplatin was used as the positive sensitivity reference standard.Compounds (7a-m) exhibited anticancer activity with IC50 values of 87.2-400 µM against prostate cancer cell lines.

Topics

Citations

OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.

33 citations

OpenAlex cited_by_count (cache / database)

56 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).

  1. Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models 2021 Citations 64 · OpenAlex
  2. Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models 2021 Citations 64 · OpenAlex
  3. Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models 2021 Citations 64 · OpenAlex
  4. Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models 2021 Citations 64 · OpenAlex
  5. Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models 2021 Citations 63 · OpenAlex
  6. Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives 2020 Citations 58 · OpenAlex
  7. Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers 2022 Citations 46 · OpenAlex
  8. Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers 2022 Citations 46 · OpenAlex
  9. Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers 2022 Citations 46 · OpenAlex
  10. Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers 2022 Citations 46 · OpenAlex

Authors

  1. MUHAMMED İHSAN HAN ERCİYES ÜNİVERSİTESİ
  2. HATİCE BEKÇİ
  3. AHMET CUMAOĞLU
  4. ŞÜKRİYE GÜNİZ KÜÇÜKGÜZEL FENERBAHÇE ÜNİVERSİTESİ