Article detail · 2013
The diagnostic and prognostic significance of SCUBE1 levels in Crimean Congo hemorrhagic fever
- Year
- 2013
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue International Journal of Infectious Diseases
- Catalog match (ISSN) International Journal of Infectious Diseases
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: The new biochemical marker, signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early embryogenesis. The protein is found in platelet and endothelial cells. Crimean-Congo hemorrhagic fever (CCHF), which is caused by a tick-borne virus belonging to the Bunyaviridae family, may present with a mild clinical course or may exhibit a severe profile with potentially fatal hemorrhaging. The aim of this study was to determine the diagnostic and prognostic significance of SCUBE1 levels in CCHF. METHODS: This study was conducted with patients with CCHF. SCUBE1 levels in patients with CCHF were determined using an ELISA. RESULTS: SCUBE1 titers of CCHF patients were significantly higher compared to those of the control group (p=0.0001). SCUBE1 levels of patients with hemorrhage were significantly higher than those of patients without hemorrhage (p=0.0001). SCUBE1 values of patients who died were significantly higher than those of the survivors (p=0.012). CONCLUSIONS: SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF. These levels are also significant as potential predictors of mortality.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
16 citations
OpenAlex cited_by_count (cache / database)
25 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- SCUBE1: a promising biomarker in renal cell cancer 2017
- SCUBE1: a promising biomarker in renal cell cancer 2017
- SCUBE1: a promising biomarker in renal cell cancer 2017
- SCUBE1: a promising biomarker in renal cell cancer 2017
- SCUBE1: a promising biomarker in renal cell cancer 2017
- The Diagnostic Value of Plasma SCUBE1 a Novel Biomarker of Platelet Activation in Testicular Torsion A Randomized Controlled Experimental Study. 2015
- The Diagnostic Value of Plasma SCUBE1 a Novel Biomarker of Platelet Activation in Testicular Torsion A Randomized Controlled Experimental Study 2015
- The Diagnostic Value of Plasma SCUBE1, a Novel Biomarker of Platelet Activation, in Testicular Torsion: A Randomized, Controlled, Experimental Study 2015
- The Diagnostic Value of Plasma SCUBE1 a Novel Biomarker of Platelet Activation in Testicular Torsion A Randomized Controlled Experimental Study 2015
- Diagnostic value of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 on serum and tissue samples in non-small cell lung cancer 2018