Article detail · 2011
The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart Liver Lungs and Kidneys in a Rat Model of Cecal Ligation and Puncture Induced Sepsis
Journal
The Scientific World JOURNALISSN 1537-744X
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2011
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue The Scientific World JOURNAL
- Catalog match (ISSN) Scientific World Journal
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
We investigated the potential protective effects of montelukast (MLK) on cecal ligation and puncture (CLP)-induced tissue injury in vital organs - liver, heart, kidneys, and especially lungs - through inhibition of the proinflammatory cytokine response and the generation of reactive oxygen species (ROS) in rats. The rat groups were (1) a 10-mg/kg MLK-treated CLP group; (2) a 20-mg/kg MLK-treated CLP group; (3) a 20-mg/kg MLK-treated, sham-operated group; (4) a CLP control group; and (5) a sham-operated control group. MLK treatment significantly decreased proinflammatory (tumor necrosis factor-alpha, interleukin-6) cytokine levels following CLP. The lipid peroxide level increased in the lung, heart, liver, and kidney tissues after CLP-induced sepsis, and myeloperoxidase activity increased in the lung, heart, and liver tissues. MLK attenuated this elevation in all tissues except the kidney, dose dependently. The glutathione levels and superoxide dismutase activity were significantly increased in the lung, liver, and kidney tissues after MLK treatment. MLK treatment after CLP also potentially reduced mortality. The lung and kidney tissues were the most protected by MLK under sepsis conditions. We can suggest that MLK reverses the systemic inflammatory reaction to polymicrobial sepsis and thereby reduces multiple organ failure.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
93 citations
OpenAlex cited_by_count (cache / database)
91 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Sepsis and Septic Shock: Current Treatment Strategies and New Approaches 2017
- The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis 2011
- The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart Liver Lungs and Kidneys in a Rat Model of Cecal Ligation and Puncture Induced Sepsis 2011
- The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart Liver Lungs and Kidneys in a Rat Model of Cecal Ligation and Puncture Induced Sepsis 2011
- The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart Liver Lungs and Kidneys in a Rat Model of Cecal Ligation and Puncture Induced Sepsis 2011
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis a biochemical and histopathological study 2011
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study 2011
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis a biochemical and histopathological study 2011
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis a biochemical and histopathological study 2011
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis a biochemical and histopathological study 2011