Article detail · 2022
Extract of Glycyrrhiza glabraroot attenuates nociception in experimental pain models: The role of BKCa channels
- Year
- 2022
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
- Catalog match (ISSN) Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
The aim of this study was to evaluate the functional interaction of Glycyrrhiza glabraroot extract (GGRE) on the large conductance Ca2+-activated K+(BKCa) channels expressed in the peripheral nervous system by using nociception and inflammation models in rodents in vivo. Besides toxicity studies and open field tests, nociception and inflammation tests were performed on rodents. Different doses of GGRE were given orally to rats and mice. Naloxone, indomethacin, morphine, NS1619 and iberiotoxin (IbTX) were administered. GGRE had both anti-nociceptive and anti-inflammatory activity in rats and mice. GGRE exhibited an analgesic effect by decreasing the time-course of the pain threshold or reaction time insome nociceptive tests. Furthermore, GGRE reduced level of pro-inflammatory cytokines, including TNF-α and IL-1β. As a conclusion, GGRE can alleviate the pain sensation of the afferent nerves and can reduce inflammation and associated pain by activating BKCa channels and reducing the levels of TNF-α, IL1β.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
5 citations
OpenAlex cited_by_count (cache / database)
2 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Glycyrrhiza glabra L. suppress the proliferation of non-small cell lung cancer by inducing necrosis rather than apoptosis despite increasing bax level 2026
- Glycyrrhiza glabra L suppress the proliferation of non-small cell lung cancer by inducing necrosis rather than apoptosis despite increasing bax level 2025