Article detail · 2018
Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study
Journal
Orthodontics & Craniofacial ResearchISSN 1601-6335
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2018
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Orthodontics & Craniofacial Research
- Catalog match (ISSN) Orthodontics and Craniofacial Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
OBJECTS: To investigate the effects of curcumin (CUR) and melatonin (MEL) on new bone formation following rapid maxillary expansion (RME) in rats. SETTING AND SAMPLE POPULATION: For this study, 24 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. MATERIALS AND METHODS: The rats were randomly divided into the following 3 groups (n = 8 each): only expansion (OE), expansion plus MEL (MEL) and expansion plus CUR (CUR). CUR and MEL were given to the rats during the study period. After the sacrifice of the animals, biochemical, histological and immunohistochemical examinations were performed. RESULTS: Serum bone alkaline phosphatase levels in the MEL group were statistically (P = .007) higher than in the OE group. Serum glutathione peroxidase and catalase activities in the CUR and MEL groups were significantly higher than in the OE group (P = .007 and P = .021, respectively). Inflammatory cell infiltration, new bone formation and capillary intensity parameters did not demonstrate statistically significant differences between the groups (P = .865, P = .067 and P = .055, respectively). The immunohistochemical findings revealed that IL-1, IL-6 and TNF-α H scores showed considerable differences between the groups (all P < .001). The highest IL-1, IL-6 and TNF-α H scores were found in the OE groups rather than in the other groups (P < .001). CONCLUSION: CUR and MEL treatments may be effective in accelerating new bone formation and beneficial in preventing relapse following the RME procedures.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
15 citations
OpenAlex cited_by_count (cache / database)
5 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- DOES SHILAJIT HAVE AN EFFECT ON NEW BONE REMODELLING IN THE RAPID MAXILLARY EXPANSION TREATMENT? A BIOCHEMICAL, HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY 2019
- Does Shilajit Have An Effect On New Bone Remodelling In The Rapid Maxillary Expansion Treatment? A Biochemıical, Histopathological And Immunohistochemical Study 2019
- Shilajit’in hızlı maksiller genişleme tedavisinde yeni kemik oluşumu üzerine etkisi var mı? Biyokimyasal, histolojik ve immünohistokimyasal bir çalışma 2019
- Does melatonin as an antioxidant and anticancer agent potentiate the efficacy of curcumin? 2023
- The effect of platelet-rich plasma on midpalatal suture in rapid maxillary expansion: An experimental study 2026