The relationship of comorbidities with clinical and phsyiological parameters in COPD

English (OpenAlex)

Chronic obstructive pulmonary disease (COPD) is defined as a systemic inflammatory disease. Systemic inflammation can start certain comorbidities or increase their severity. This study aims to assess the relationship of comorbid diseases with clinical and physiological parameters. The study enrolled 115 patients (15 female, 100 male) who are on regular follow-up in COPD outpatient clinic. In each patient the presence of cardiovascular disease (hypertension, coronary artery disease, arrhythmia, heart failure), hyperlipidemia, cachexia, malignancy, diabetes, osteoporosis, anxiety disorder, depression, obstructive sleep apnea, and anemia was questioned. The most frequent diseases were hypertension, coronary artery disease, and hyperlipidemia (43,9%, 39,6%, 27,4%, respectively). Cardiovascular diesases were more common in those with a FEV1 percent below 50 (r=0,10; p In patients with a high Charlson Comorbidity Index (CCI) coronary artery disease (r=0,032; p As a conclusion, disease stage and hypoxemia level are related to concomittant cardiovascular system diseases. A more than expected deterioration in general health status is observed in COPD patients with comorbidities.