Article detail · 2026
Electrospun PVA/CS/HA/BA Nanofiber Scaffolds with Enhanced Mechanical Stability and Antifungal Activity for Bone Tissue Engineering
- Year
- 2026
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Materials
- Catalog match (ISSN) Materials
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
In this study, we created multifunctional bone tissue engineering scaffolds that combine prophylactic antifungal action with structural support. We produced PVA/CS/HA/BA nanofiber matrices via a specifically designed electrospinning technique to stop early cross-linking. Through SEM, our examination of fiber shape revealed diameters ranging from 178 ± 53 nm to 330 ± 69 nm. We discovered that this variation was closely correlated with the Boric Acid (BA) level. Our EDS and FTIR studies further showed that HA and BA were effectively mixed, with a specific focus on the production of borate-ester linkages inside the network. Mechanical examination revealed that 0.25 wt.% BA maximizes the tensile strength at 9.15 MPa, thereby closely matching HA-reinforced standards, while HA incorporation improved thermal stability. Moreover, in vitro hFOB experiments showed sustained cytocompatibility at 0.25 wt.% BA. While 0.5 wt.% BA showed strong antifungal action against Candida albicans, it sadly harmed cell viability. The 0.25 wt.% BA concentration ultimately offers a better balance between mechanical integrity and antibacterial action, therefore presenting a potential method for scaffold generation for bone regeneration in immunocompromised patients.
Topics
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
Primary topic Electrospun Nanofibers in Biomedical Applications