Article detail · 2011
The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans
- Year
- 2011
- Type
- article
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- YÖKSİS YÖKSİS article record
- YÖKSİS venue Science
- Catalog match (ISSN) Science
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.
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Citations
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564 citations
OpenAlex cited_by_count (cache / database)
6 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Altitude adaptation in Tibetans caused by introgression of Denisovan like DNA 2014
- Worldwide Patterns of Ancestry Divergence and Admixture in Domesticated Cattle 2014
- Genetic origin of Behçet’s disease population in Denizli, Turkey population genetics data analysis historical demography and geographical perspectives based on β-globin gene cluster haplotype variation 2017
- Genetic origin of Behçet s disease population in Denizli Turkey population genetics data analysis historicaldemography and geographical perspectives based on globin gene cluster haplotype variation 2017
- Genetics of Behçet’s Disease 2019
- What Do the Genetic Studies Tell Us About Behçet Disease? 2025