Article detail · 2016
Preparation and in vivo evaluation of dimenhydrinate buccal mucoadhesive films with enhanced bioavailability
- Year
- 2016
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Drug Development and Industrial Pharmacy
- Catalog match (ISSN) Drug Development and Industrial Pharmacy
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Dimenhydrinate (DMH)-loaded buccal bioadhesive films for the prevention and treatment of motion sickness were prepared and optimized. This study examines the rate of drug release from the films for prolonged periods of time to reduce or limit the frequency of DMH administration. Based on preliminary studies using various polymers and concentrations, hydroxyethylcellulose (2.5, 3.0, and 3.2%), and xanthan gum (2.8%) were chosen as matrix polymers. The films were analyzed with respect to their mechanical, physicochemical, bioadhesive, swelling, and in-vitro release properties. In in-vivo pharmacokinetic studies, xanthan gum-based DMH buccal film was associated with significantly increased DMH plasma levels between 1 h and 5 h after DMH dosing when compared with an oral drug solution. The area under the curve AUC0-7 h value of the mucoadhesive buccal film was two-fold higher than the oral DMH solution. Histological analysis revealed that DMH films cause mild morphological and inflammatory changes in rabbit buccal mucosa. The DMH buccal film is effective for approximately 7 h, thus representing an option for single-dose antiemetic therapy. This dosage regimen could be particularly beneficial for chain travelers who travel for long periods of time.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
25 citations
OpenAlex cited_by_count (cache / database)
6 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis 2023
- Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis 2022
- Investigation of Binding Interaction Behavior between Antiemetic Drugs and Trypsin by Spectroscopy and Molecular Docking 2021
- Investigation of binding interaction behavior between antiemetic drugs and Trypsin by spectroscopy and molecular docking 2021
- Preparation and In Vitro Evaluation of Montelukast Sodium-Loaded 3D Printed Orodispersible Films for the Treatment of Asthma 2024
- Fusidic Acid-Loaded Wound Dressing Films Using 3D Printing Technology with a Quality by Design Approach 2026