Article detail · 2020
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
- Year
- 2020
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Clinical Medicine
- Catalog match (ISSN) Journal of Clinical Medicine
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article review the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
250 citations
OpenAlex cited_by_count (cache / database)
13 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation 2022
- The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies 2022
- The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies 2022
- Guava (Psidium guajava L.) seed: A low-volume, high-value byproduct for human health and the food industry 2022
- Therapeutic Potential of Neoechinulins and Their Derivatives: An Overview of the Molecular Mechanisms Behind Pharmacological Activities 2021
- Protein and Gene Delivery Systems for Neurodegenerative Disorders: Where Do We Stand Today? 2022
- Protein and Gene Delivery Systems for Neurodegenerative Disorders: Where Do We Stand Today? 2022
- Protein and Gene Delivery Systems for Neurodegenerative Disorders: Where Do We Stand Today? 2022
- Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide 2022
- Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model 2020