Article detail · 2019
The protective role of jervine against radiation-induced gastrointestinal toxicity
- Year
- 2019
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Catalog match (ISSN) Journal of Enzyme Inhibition and Medicinal Chemistry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
9 citations
OpenAlex cited_by_count (cache / database)
14 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Protective Effects of Jervine Purified From Veratrum Album on Paracetamol-Induced Liver Toxicity in Rats 2024
- Protective effects of jervine purified from Veratrum album on paracetamol-induced liver toxicity in rats 2024
- Sıçanlarda parasetamolle indüklenen karaciğer toksisitesi üzerine Veratrum album bitkisinden saflaştırılan jervinin koruyucu etkisi 2024
- Protective effects of jervine purified from Veratrum album on paracetamol-induced liver toxicity in rats 2024
- Protective effect and results of glutamine and partially hydrolyzed Guar gum on rats with experimental radiation enteritis 2026
- Protective effect and results of glutamine and partially hydrolyzed Guar gum on rats with experimental radiation enteritis 2026
- Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat 2025
- Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat 2025
- Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat 2025
- Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat 2025