Article detail · 2015
Boric acid a simple molecule of physiologic therapeutic and prebiotic significance
Journal
Pure and Applied Chemistry, (Q1)ISSN 0033-4545
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2015
- External link
- https://dx.doi.org/DOI: 10.1515/pac-2014-0909
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Pure and Applied Chemistry, (Q1)
- Catalog match (ISSN) Pure and Applied Chemistry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract Boric acid, H 3 BO 3 , is a weak acid and at physiological pH is in the form of an uncharged small molecule. Behaving as a Lewis acid, it forms complexes with amino- and hydroxy acids, carbohydrates, nucleotides and vitamins through electron donor-acceptor interactions. These interactions are believed to be beneficial for human health. Synthetic bis- chelate complexes of boric acid with organic biomolecules are therefore considered for nutritional and/or pharmaceutical applications. The use of boric acid for BNCT has gained attention due to the short biological half-life, solubility, plasma circulation and the non-selective soft tissue accumulation properties of this simple molecule. Complexation of boric acid with sugars is of particular importance in understanding the role of boron as a carrier for nucleotides and carbohydrates. A potential and catalytic role of boric acid in peptide and nucleic acid synthesis and in the stabilization of sugar molecules by acting as a complexing agent have been demonstrated. Its possible role as a phosphorylation chaperone in a prebiotic world has been recently suggested. This contribution reviews the highlights in the physiologic, therapeutic and prebiotic significance of boric acid in the last decade.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
48 citations
OpenAlex cited_by_count (cache / database)
50 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Gadolinium borate and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications 2018
- Antibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogens. 2024
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- Antibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogens 2023
- Antibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogens 2023
- Boron Compound–Based Treatments Against Multidrug-Resistant Bacterial Infections in Lung Cancer In Vitro Model 2023
- Therapeutic Effects of Newly Synthesized Boron Compounds (BGM and BGD) on Hepatocellular Carcinoma 2022