Article detail · 2023
Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates
YÖKSİS
OpenAlex
SJR Q3
JCR Q2
Citations 9
Percentile 56.5%
FWCI 0.57
- Year
- 2023
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Heterocyclic Chemistry
- Catalog match (ISSN) Journal of Heterocyclic Chemistry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
Abstract In this study, 10 new indole‐dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF‐7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 μM concentrations, while only compound 5 showed better activity than docatexel, the MCF‐7 cell line at 0.1 and 1 μM concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work.
Topics
- Synthesis and biological activity
- Free Radicals and Antioxidants
- Computational Drug Discovery Methods
Primary topic Synthesis and biological activity