Telomeres, Telomerase, and Senescence

Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. Identifying secreted factors that achieve such tasks is a challen…

Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. Identifying secreted factors that achieve such tasks is a challen…

• MUSTAFA BURAK ACAR

UNLABELLED: Senescence induction could be used as an effective treatment for hepatocellular carcinoma (HCC). However, major senescence inducers (p53 and p16(Ink4a)) are frequently inactivated in these cancers. We tested whether transforming growth factor-beta (TGF-beta) could serve as a potential senescence inducer in…

• MEHMET ÖZTÜRK

UNLABELLED: Senescence induction could be used as an effective treatment for hepatocellular carcinoma (HCC). However, major senescence inducers (p53 and p16(Ink4a)) are frequently inactivated in these cancers. We tested whether transforming growth factor-beta (TGF-beta) could serve as a potential senescence inducer in…

• KAMİL CAN AKÇALI

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• MENDERES YUSUF TERZİ
• MÜZEYYEN İZMİRLİ

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• MÜZEYYEN İZMİRLİ

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Reactive oxygen species (ROS) appear to play a role in limiting both cellular and organismic lifespan. However, because of their pleiotropic effects, it has been difficult to ascribe a specific role to ROS in initiating the process of cellular senescence. We have studied the effects of oxidative DNA damage on cell pro…

• TEVFİK TAMER ÖNDER

Reactive oxygen species (ROS) appear to play a role in limiting both cellular and organismic lifespan. However, because of their pleiotropic effects, it has been difficult to ascribe a specific role to ROS in initiating the process of cellular senescence. We have studied the effects of oxidative DNA damage on cell pro…

• TEVFİK TAMER ÖNDER

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// Kyle M. Walsh 1,2 , Veryan Codd 3,4 , Terri Rice 1 , Christopher P. Nelson 3,4 , Ivan V. Smirnov 5 , Lucie S. McCoy 1 , Helen M. Hansen 1 , Edward Elhauge 1 , Juhi Ojha 1 , Stephen S. Francis 5 , Nils R. Madsen 1 , Paige M. Bracci 6 , Alexander R. Pico 7 , Annette M. Molinaro 5 , Tarik Tihan 8 , Mitchel S. Berger 5…

Telomeres are located at the ends of all eukaryotic chromosomes and protect them from deleterious events such as inappropriate DNA repair, illegitimate recombination or improper segregation of the chromosomes during mitotic or meiotic divisions. However, telomeres gradually shorten primarily due to successive rounds o…