Article detail · 2007
Major depressive disorder is accompanied with oxidative stress short term antidepressant treatment does not alter oxidative antioxidative systems
Journal
Human Psychopharmacology: Clinical and ExperimentalISSN 0885-6222
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2007
- DOI
- 10.1002/hup.829
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Human Psychopharmacology: Clinical and Experimental
- Catalog match (ISSN) Human Psychopharmacology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
OBJECTIVE: The aim of the present study was to investigate the oxidative-antioxidative systems and effects of different antidepressants on these systems in patients with major depressive disorder (MDD). METHOD: Ninety-six patients with a Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) diagnosis of MDD and 54 healthy controls were included in the study. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cells (RBCs) to oxidation were determined to investigate the oxidative status, plasma vitamin E, vitamin C, serum total carotenoid levels, total antioxidant capacity (TAOC), RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase (GPx) activities were measured to investigate the antioxidative defence before and after 6 weeks of antidepressant treatment. RESULTS: Plasma MDA levels and susceptibility of RBCs to oxidation were significantly higher in the MDD group compared with the control group. RBC SOD activity was significantly increased in patients with MDD, and furthermore there was a significant positive correlation between the severity of the disease and SOD activity. CONCLUSION: MDD is accompanied with oxidative stress; however, oxidative-antioxidative systems do not seem to be affected by 6 weeks of antidepressant treatment.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
498 citations
OpenAlex cited_by_count (cache / database)
18 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Effects of long term antidepressant treatment on oxidative status in major depressive disorder A 24 week follow up study 2011
- Evaluation of malondialdehyde superoxide dismutase and catalase activity and their diagnostic value in drug naïve first episode non smoker major depression patients and healthy controls 2016
- Evaluation of malondialdehyde superoxide dismutase and catalase activity and their diagnostic value in drug naïve first episode non smoker major depression patients and healthy controls 2016
- The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies 2016
- The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies 2016
- Possible role of selective serotonin reuptake inhibitor sertraline on oxidative stress responses. 2014
- The renoprotective effects of mannitol and udenafil in renal ischemia-reperfusion injury model 2017
- The use of biomarkers in the diagnosis and treatment of overactive bladder: Can we predict the patients who will be resistant to treatment? 2017
- The Effects of Escitalopram Treatment on Oxidative/ Antioxidative Parameters in Patients with Depression 2015
- The Effects of Escitalopram Treatment on Oxidative/ Antioxidative Parameters in Patients with Depression 2015