Article detail · 2023
Functional effects of human milk oligosaccharides (HMOs)
- Year
- 2023
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Gut Microbes
- Catalog match (ISSN) Gut Microbes
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables, such as secretor status, race, geographic region, environmental conditions, season, maternal diet, and weight, gestational age and mode of delivery. HMOs improve the gastrointestinal barrier and also promote a bifidobacterium-rich gut microbiome, which protects against infection, strengthens the epithelial barrier, and creates immunomodulatory metabolites. HMOs fulfil a variety of physiologic functions including potential support to the immune system, brain development, and cognitive function. Supplementing infant formula with HMOs is safe and promotes a healthy development of the infant revealing benefits for microbiota composition and infection prevention. Because of limited data comparing the effect of non-human oligosaccharides to HMOs, it is not known if HMOs offer an additional clinical benefit over non-human oligosaccharides. Better knowledge of the factors influencing HMO composition and their functions will help to understand their short- and long-term benefits.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
228 citations
OpenAlex cited_by_count (cache / database)
10 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition 2024
- Prebiotics: types, selectivity and utilization by gut microbes 2025
- Breastfeeding and Health Benefits for the Mother-Infant Dyad: A Perspective on Human Milk Microbiota. 2025
- Composition of Microbiota in Transient and Mature Human Milk: Significant Changes in Large for Gestational Age Group 2024
- Composition of Microbiota in Transient and Mature Human Milk: Significant Changes in Large for Gestational Age Group 2024
- Potential Health Benefits of Human and Animal Milks: A Critical Review of the Current Literature 2026
- Valorization of dairy by-products for milk-based infant formulas: A nutritional perspective review 2026
- Meningococcal Carriage in Children with Atypical Hemolytic Uremic Syndrome Receiving Eculizumab Therapy 2024
- Clostridioides difficile Infections: Prevention and Treatment Strategies 2024
- Effect of maternal miRNAs and milk oligosaccharides on regulating the growth behavior of Bifidobacterium longum subsp. infantis 2025