Article detail · 2009
Factorial design optimization and iin vivo/i feasibility of poly(ε-caprolactone)-micro- and nanofiber-based small diameter vascular grafts/title
Journal
Journal of Biomedical Materials Research Part AISSN 1549-3296
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Biomedical Materials Research Part A
- Catalog match (ISSN) Journal of Biomedical Materials Research - Part A
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Because of the severe increase of mortality by cardiovascular diseases, there has been rising interest among the tissue-engineering community for small-sized blood vessel substitutes. Here we present small diameter vascular grafts made of slow degradable poly(epsilon-caprolactone) nanofibers obtained by electrospinning. The process was optimized by a factorial design approach that led to reproducible grafts with inner diameters of 2 and 4 mm, respectively. Fiber sizes, graft morphology, and the resulting tensile stress and tensile strain values were studied as a function of various parameters in order to obtain optimal vascular grafts for implantation after gamma-sterilization. The influence of polymer concentration, solvent, needle-collector distance, applied voltage, flow rate, and spinning time has been studied. Consequently, an optimized vascular graft was implanted as an abdominal aortic substitute in nine rats for a feasibility study. Results are given following up a 12-week implantation period showing good patency, endothelization, and cell ingrowth.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
151 citations
OpenAlex cited_by_count (cache / database)
4 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Degradation and Healing Characteristics of Small-Diameter Poly( -Caprolactone) Vascular Grafts in the Rat Systemic Arterial Circulation 2008
- Emulsion templated scaffolds manufactured from photocurable polycaprolactone 2019
- Paclitaxel-Eluting Biodegradable Synthetic Vascular Prostheses: A Step Towards Reduction of Neointima Formation? 2009
- Pro-angiogenic small-diameter tissue-engineered vascular grafts (TEVGs) fabricated from 2-deoxy-D-ribose (2dDR)-incorporated electrospun polycaprolactone (PCL) fibers 2026