Article detail · 2020
Serum zonulin and claudin-5 levels in children with obsessive\compulsive disorder
- Year
- 2020
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Nordic Journal of Psychiatry
- Catalog match (ISSN) Nordic Journal of Psychiatry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Background: Obsessive–compulsive disorder (OCD), a chronically debilitating neuropsychiatric disorder, is characterized by distinctive and recurrent obsessions and/or compulsions. An increasing number of evidence indicates that sophisticated interactions between different neurobiological factors play a part in OCD etiology, but the certain underlying mechanisms are still mainly unknown. The present research aimed to explore whether the concentrations of serum zonulin and claudin-5 vary between OCD patients and healthy controls. The present research also intended to explore whether there is an association between zonulin and claudin-5 concentrations and OCD severity.Methods: Twenty-four (13 boys and 11 girls) OCD patients and 24 (13 boys and 11 girls) healthy controls were included in this study. The clinical severity of the OCD symptoms was evaluated by the Children’s Yale-Brown Obsessive–Compulsive Scale and the Maudsley Obsessive–Compulsive Inventory. Participants also filled out the Revised Child Anxiety and Depression Scales-Child Version to determine the anxiety and depression levels of the children. Venous blood samples were collected, and serum zonulin and claudin-5 levels were measured.Results: Serum claudin-5 levels were found to be significantly higher in OCD patient whereas serum zonulin levels were not significantly different between the groups.Conclusions: Taken together with our results, our study suggests that dysregulation of the blood–brain barrier, especially claudin-5, may be involved in the etiology of OCD.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
42 citations
OpenAlex cited_by_count (cache / database)
41 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Serum zonulin and claudin-5 levels in patients with schizophrenia 2021
- Serum zonulin and claudin-5 levels in patients with schizophrenia 2021
- Serum zonulin and claudin-5 levels in patients with schizophrenia 2021
- Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder 2021
- Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder 2021
- Evaluation of Serum Zonulin and Occludin Levels in Bipolar Disorder 2023
- Investigation of Relaxin-3 Serum Levels in terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism 2022
- Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder 2022
- EVALUATION OF BLOOD ZONULIN LEVELS, INFLAMMATORY PROCESSES AND NEURONAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER 2022
- Zonulin and claudin‐5 levels in multisystem inflammatory syndrome and SARS‐CoV‐2 infection in children 2022