Article detail · 2013
The role of uric acid in the pathogenesis of human cardiovascular disease
- Year
- 2013
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Heart
- Catalog match (ISSN) Heart
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
466 citations
OpenAlex cited_by_count (cache / database)
42 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Uric acid as a potential mediator of cardiovascular morbidity in obstructive sleep apnea syndrome 2014
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- Relationship Between Elevated Morning Blood Pressure Surge, Uric Acid, and Cardiovascular Outcomes in Hypertensive Patients 2014
- Relationship betweenelevated morning blood pressure surge uric acid and cardiovascular outcomes in hypertensive patients 2014
- Relationship Between Elevated Morning Blood Pressure Surge Uric Acid and Cardiovascular Outcomes in Hypertensive Patients 2014
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- Serum neutrophil gelatinase associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease 2015