Article detail · 2009
Atorvastatin Prevents Gentamicin Induced Renal Damage in Rats through the Inhibition of p38 MAPK and NF kB Pathways
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Renal Failure
- Catalog match (ISSN) Renal Failure
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND AND AIMS: Gentamicin (GM) is still considered to be an important antibiotic against life-threatening, gram-negative bacterial infections despite its known nephrotoxic effects. We aimed to evaluate the potential protective effect of atorvastatin (ATO) against GM-induced nephrotoxicity in rats. MATERIALS AND METHODS: The rats were randomly divided into five groups of six animals each: control, GM (100 mg/kg/day), ATO (10 mg/kg/day), GM + ATO, and GM + Vehicle. Kidney function tests, tissue oxidative stress parameters, and histopathological and immunohistochemical studies clarified GM nephrotoxicity. RESULTS: GM caused a marked reduction in renal functions and increased oxidative stress parameters. Histopathological examination revealed tubular necrosis especially in the renal cortex in GM rats. On immunohistochemical evaluation, GM rat showed more intense expressions of mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-kappaB), and inducible nitric oxide synthase (iNOS) compared with control. Kidney function tests and tissue oxidative stress parameters were normalized in the GM + ATO group. Histopathological and immunohistochemical pictures were also greatly ameliorated. CONCLUSIONS: ATO acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM via the inhibition of MAPK and NF-kappaB signaling pathways and iNOS expression.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
124 citations
OpenAlex cited_by_count (cache / database)
36 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- The Effects of Vitamin D on Gentamicin Induced Acute Kidney Injury in Experimental Rat Model 2013
- The Effects of Vitamin D on Gentamicin Induced Acute Kidney Injury in Experimental Rat Model 2013
- The Effects of Vitamin D on Gentamicin Induced Acute Kidney Injury in Experimental Rat Model 2013
- The Effects of Vitamin D on Gentamicin Induced Acute Kidney Injury in Experimental Rat Model 2013
- The Effects of Vitamin D on Gentamicin Induced Acute Kidney Injury in Experimental Rat Model 2013
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- Physiological and biochemical effects of nickel on rainbow trout Oncorhynchus mykiss tissues Assessment of nuclear factor kappa B activation oxidative stress and histopathological changes 2017
- Physiological and biochemical effects of nickel on rainbow trout (Oncorhynchus mykiss) tissues: Assessment of nuclear factor kappa B activation, oxidative stress and histopathological changes 2017
- Protective Effect of Montelukast Which Is Cysteinyl-Leukotriene Receptor Antagonist on Gentamicin-Induced Nephrotoxicity and Oxidative Damage in Rat Kidney 2013
- Protective Effect of Montelukast Which Is Cysteinyl-Leukotriene Receptor Antagonist on Gentamicin-Induced Nephrotoxicity and Oxidative Damage in Rat Kidney 2013