Article detail · 2026
Wound healing activities of eucalyptol on full thickness excisional skin wound model in rats
Journal
Ankara Üniversitesi Veteriner Fakültesi DergisiISSN 1300-0861
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- Year
- 2026
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Ankara Üniversitesi Veteriner Fakültesi Dergisi
- Catalog match (ISSN) Ankara Universitesi Veteriner Fakultesi Dergisi
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
A plant-derived monoterpene, eucalyptol (1,8-cineole), has been suggested to have antioxidant, anti-inflammatory, and antimicrobial properties. The wound-healing effects of eucalyptol remain unknown. This study aimed to evaluate the topical use of eucalyptol at two concentrations on a full-thickness excisional skin wound model in terms of wound healing, gene expression, biochemical changes, and histopathological changes. Sixty Wistar rats were randomly divided into 5 groups (n = 12 per group). The control group (C) was untreated. Full-thickness excisional skin wounds were created in the following groups: the vehicle group (V), which was treated with polysorbate 80 solution (negative control). The Dexpanthenol group (D) was treated with dexpanthenol ointment (positive control). Eucalyptol 5% (E5) and Eucalyptol 10% (E10) groups were treated with 5% and 10% eucalyptol, respectively. Wound areas were measured on days 1, 4, 7, 11, 14, 18, and 21 days after wound creation. Wound tissues were collected on days 7 and 21. Histopathological, gene expression (TNFα, IL10, TGFβ1, VEGF), and biochemical (MDA, rGSH, GPx, CAT) analyses were performed on the wound tissues. TNFα gene expression levels were upregulated in Groups V and E5 (P
Topics
Citations
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2 citations
OpenAlex cited_by_count (cache / database)
3 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Topical eucalyptol accelerates the healing of MRSA-infected diabetic wounds in rats by regulating TLR4, NF-κB, VEGFA and MMP-9 pathways 2026
- Topical eucalyptol accelerates the healing of MRSA-infected diabetic wounds in rats by regulating TLR4, NF-κB, VEGFA and MMP-9 pathways 2026
- Chlorogenic acid attenuates malondialdehyde levels and regulates major ferroptosis-related genes in testes of acrylamide-exposed rats 2026