Article detail · 2024
Nanoencapsulation of a Far-Red Absorbing Phthalocyanine into Poly(benzylmalate) Biopolymers and Modulation of Their Photodynamic Efficiency
- Year
- 2024
- ISSN
1525-7797- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
High Resolution Image Download MS PowerPoint Slide Two different poly(benzylmalate) biopolymers, a hydrophobic non-PEGylated ( PMLABe 73 ) and an amphiphilic PEGylated derivative ( PEG 42 - b -PMLABe 73 ), have been used to encapsulate a phthalocyanine chosen for its substitution pattern that is highly suitable for photodynamic therapy. Different phthalocyanine/(co)polymers ratios have been used for the nanoprecipitation. A set of six nanoparticles has been obtained. If the amphiphilic PEGylated copolymer proved to be slightly more efficient for the encapsulation and to lower the aggregation of the phthalocyanine inside the nanoparticles, it is, however, the hydrophobic PMLABe 73 -based nanoparticles that exhibited the best photodynamic efficiency.
Topics
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
Primary topic Porphyrin and Phthalocyanine Chemistry