Article detail · 2010
Mutagenic and Antimutagenic Effects of Hexane Extract of some AstragalusSpecies Grown in the Eastern Anatolia Region of Turkey
- Year
- 2010
- DOI
- 10.1002/ptr.3059
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue PHYTOTHERAPY RESEARCH
- Catalog match (ISSN) Phytotherapy Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Medical plants and their various extracts have been occasionally used in the treatment of many diseases. Astragalus is one of those medical plants and it has several biological activities. In the present study, the hexane extracts of six Astragalus species, which are grown in the eastern Anatolia region of Turkey, were isolated, and their mutagenic and antimutagenic properties were investigated by using Salmonella typhimurium TA1535, TA1537 and Escherichia coli WP2uvrA tester strains at 0.05, 0.5 and 5 microg/plate concentrations. Known mutagens sodium azide (NaN(3)), 9-Aminoacridine (9-AA) and N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) were used to determine antimutagenic properties of hexane extracts. The results showed that all hexane extracts, investigated in the present study, can be considered genotoxically safe because they do not have mutagenic activity at the tested concentrations. But, a great many of them have antimutagenic activity against 9-Aminoacridine known as a model intercalator agent. The inhibition rates obtained from the antimutagenicity assays ranged from 27.51% (A. macrocephalus--0.05 microg/plate) to 54.39% (A. galegiformis--5 microg/plate). These activities are valuable toward an extension of the employ of these drugs as new phytotherapeutic or preservative ingredients.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
59 citations
OpenAlex cited_by_count (cache / database)
103 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Isolation of some luteolin derivatives from Mentha longifolia L Hudson subsp longifolia and determination of their genotoxic potencies 2012
- Isolation of some luteolin derivatives from Mentha longifolia L Hudson subsp longifolia and determination of their genotoxic potencies 2012
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- Isolation of some active compounds from Origanum vulgare L. ssp vulgare and determination of their genotoxic potentials 2012
- Isolation of some active compounds from Origanum vulgare L. ssp vulgare and determination of their genotoxic potentials 2012
- Isolation of some active compounds from Origanum vulgare L ssp vulgare and determination of their genotoxic potentials 2012