Article detail · 2014
Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia
- Year
- 2014
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Blood Cancer Journal
- Catalog match (ISSN) Blood Cancer Journal
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients. To evaluate the potential role of WNT signaling in T-cell leukomogenesis, we performed expression analysis of key components of WNT pathway. More than 85% of the childhood T-ALL patients showed upregulated β-catenin expression at the protein level compared with normal human thymocytes. The impact of this upregulation was reflected in high expression of known target genes (AXIN2, c-MYC, TCF1 and LEF). Especially AXIN2, the universal target gene of WNT pathway, was upregulated at both mRNA and protein levels in ∼40% of the patients. When β-CATENIN gene was silenced by small interfering RNA, the cancer cells showed higher rates of apoptosis. These results demonstrate that abnormal WNT signaling activation occurs in a significant fraction of human T-ALL cases independent of known T-ALL risk factors. We conclude that deregulated WNT signaling is a novel oncogenic event in childhood T-ALL.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
72 citations
OpenAlex cited_by_count (cache / database)
23 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia 2015
- A possible role for WNT5A hypermethylation in Pediatric Acute Lymphoblastic Leukemia 2015
- A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia 2015
- A possible role for WNT5A hypermethylation in Pediatric Acute Lymphoblastic Leukemia 2015
- Dysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia 2017
- Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia 2021
- Prognostic Evidence of LEF1 Isoforms in Childhood Acute Lymphoblastic Leukemia 2021
- Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia 2021
- Differential Expression of LEF1 Isoforms in Adult Lymphoid and Myeloid Malignancies 2021
- β-catenin mutations in acute myeloid leukemia 2021