Article detail · 2007
Effects of thymoquinone (Volatile oil of black cumin) on rheumatoid arthritis in rat models
- Year
- 2007
- DOI
- 10.1002/ptr.2143
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue PHYTOTHERAPY RESEARCH
- Catalog match (ISSN) Phytotherapy Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Many studies have been carried out in recent years on the pharmacological effects of Nigella sativa seeds that have uncovered their antiinflammatory and immunological effects. The objective of this study was to explore the antiinflammatory effects of thymoquinone on arthritis in rat models. Rats with arthritis induced by Freund's incomplete adjuvant were assigned to five groups: group 1: controls 0.9% NaCl (n = 7); group 2: 2.5 mg/kg thymoquinone (n = 7); group 3: 5 mg/kg thymoquinone (n = 7); group 4: Bacilli Chalmette Guerin (BCG) 6 x 105 CFU (n = 7); group 5: methotrexate 0.3 mg/kg (n = 7). Signs of inflammation on the claw and radiological signs were searched for and TNF-alpha and IL-1beta were measured. The results of the control and other groups were compared. As a result, thymoquinone, confirmed clinically and radiologically, suppressed adjuvant-induced arthritis in rats.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
198 citations
OpenAlex cited_by_count (cache / database)
41 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis 2016
- The combination of thymoquinone and paclitaxel shows anti tumor activity through the interplay with apoptosis network in triple negative breast cancer 2016
- The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. 2016
- Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study 2012
- Preventive effects of thymoquinone in a rat periodontitis model a morphometric and histopathological study 2012
- Preventive effects of thymoquinone in a rat periodontitis model a morphometric and histopathological study 2012
- Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure 2012
- Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure 2011
- A Review on Extraction, Characterization, and Applications of Bioactive Peptides From Pressed Black Cumin Seed Cake 2021
- Evaluation of the Effect of Thymoquinone Treatment on Wound Healing in a Rat Burn Model 2013