Article detail · 2023
Pendant isocyanate and epoxide-containing copolymers: synthesis, sequentialdual-functionalization with amines, and surface modifications
Journal
Journal of Macromolecular Science, Part A Pure and Applied ChemistryISSN 1060-1325
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2023
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Macromolecular Science, Part A Pure and Applied Chemistry
- Catalog match (ISSN) Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Polymers carrying different reactive groups that can be orthogonally functionalized are desirable for the design of multi-functionalizable materials. While several orthogonally functionalizable polymers have been reported, most of the work utilizes handles that are reactive toward different functional groups. However, examples of polymers that are orthogonally reactive toward molecules bearing the same functional group are rare. In this work, we report polymeric materials that can be sequentially functionalized using different amine-bearing molecules. Herein, we synthesized isocyanate and epoxide group containing copolymers, and investigated their sequential functionalization with amine-containing molecules. We show that such copolymers can be first functionalized with a particular amine-bearing molecule at room temperature, using conjugation through the isocyanate group. Thereafter, a different amine-containing molecule can be attached through the epoxy-amine reaction at 65 °C. Chemical characterizations of parent and subsequently functionalized copolymers were done by 1H NMR and FTIR spectroscopy techniques, to establish orthogonal functionalization. Additionally, the epoxide side chains were utilized as surface anchoring group after the functionalization of the polymer via isocyanate-amine reaction. This straightforward approach for obtaining orthogonally reactive amine-functionalizable copolymers, and surfaces derived thereof, would be attractive materials for various biomedical applications.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
7 citations
OpenAlex cited_by_count (cache / database)
10 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Preparation of isocyanate-containing hydrogel films as antibacterial enzyme immobilization matrices 2023
- Preparation of isocyanate-containing hydrogel films as antibacterial enzyme immobilization matrices 2023
- Preparation of isocyanate-containing hydrogel films as antibacterial enzyme immobilization matrices 2023
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