Article detail · 2022
The effect of local application of thymoquinone, Nigella sativa ’s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis
- Year
- 2022
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue journal of periodontal and implant science
- Catalog match (ISSN) Journal of Periodontal and Implant Science
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
PURPOSE: (PG). METHODS: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. RESULTS: <0.05). CONCLUSIONS: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.
Topics
- Nigella sativa pharmacological applications
- Bone Metabolism and Diseases
- Oral health in cancer treatment
Primary topic Nigella sativa pharmacological applications