Preoperative De Ritis Ratio for the Evaluation of Recurrence and Progression in Non-muscle Invasive Bladder Cancer

English (OpenAlex)

Objective: This study aimed to investigate the potential predictive value of the preoperative De Ritis ratio in patients with primary non-muscle invasive bladder cancer (NMIBC).Materials and Methods: Of 212 patients who underwent transurethral resection of bladder tumour surgery for primary bladder cancer at a single academic centre between 2010 and 2016, we retrospectively analysed the clinical and pathological data.Blood samples were collected 1-7 days before surgery.The De Ritis ratio's potential prognostic value of was evaluated using receiver operating characteristic (ROC) curve analysis.Results: One hundred twenty-five patients (or 59%) were found to have high-risk diseases, 17 patients (or 8%) had intermediate-risk diseases, and 70 patients (or 33%) had low-risk diseases.We investigated which cut-off value for De Ritis ratio could predict NMIBC risk groups in the preoperative period.The ROC analysis showed that there was no significant cut-off value in either low-risk [area under the curve (AUC)=0.457]or high-risk (AUC=0.551)patients.According to the European Organization for Research and Treatment of Cancer risk groups, when the quantitative values were compared, it was seen that low-risk patients were younger (p=0.005) and this group's alanine aminotransaminase (p<0.001)values were higher.De Ritis ratio was statistically similar in all patient groups.Conclusion: According to our present results, the De Ritis ratio does not add any additional value to existing prognostic models.Investigating De Ritis ratio simultaneously with markers such as albumin, C-reactive protein, neutrophil-lymphocyte ratio, which are used successfully in many cancer types, may yield successful results in prospective, more comprehensive studies.