Article detail · 2012
Assessment of imidacloprid toxicity on reproductive organ system of adult male rats
Journal
Journal of Environmental Science and Health, Part BISSN 0360-1234
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2012
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Environmental Science and Health, Part B
- Catalog match (ISSN) Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
In the current study it was aimed to investigate the toxicity of low doses of imidacloprid (IMI) on the reproductive organ systems of adult male rats. The treatment groups received 0.5 (IMI-0.5), 2 (IMI-2) or 8 mg IMI/kg body weight by oral gavage (IMI-8) for three months. The deterioration in sperm motility in IMI-8 group and epidydimal sperm concentration in IMI-2 and IMI-8 groups and abnormality in sperm morphology in IMI-8 were significant. The levels of testosterone (T) and GSH decreased significantly in group IMI-8 compared to the control group. Upon treatment with IMI, apoptotic index increased significantly only in germ cells of the seminiferous tubules of IMI-8 group when compared to control. Fragmentation was striking in the seminal DNA from the IMI-8 group, but it was much less obvious in the IMI-2 one. IMI exposure resulted in elevation of all fatty acids analyzed, but the increases were significant only in stearic, oleic, linoleic and arachidonic acids. The ratios of 20:4/20:3 and 20:4/18:2 were decreased and 16:1n-9/16:0 ratio was increased. In conclusion, the present animal experiments revealed that the treatment with IMI at NOAEL dose-levels caused deterioration in sperm parameters, decreased T level, increased apoptosis of germ cells, seminal DNA fragmentation, the depletion of antioxidants and change in disturbance of fatty acid composition. All these changes indicate the suppression of testicular function.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
120 citations
OpenAlex cited_by_count (cache / database)
21 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats 2013
- Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats 2013
- Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats 2013
- Abnormal sperm morphology in mouse germ cells after short term exposures to acetamiprid propineb and their mixture 2014
- Biochemical alterations in kidneys of infant and adult male rats due to exposure to the neonicotinoid insecticides imidacloprid and clothianidin 2014
- Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats 2023
- Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats 2023
- Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats 2023
- Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats 2023
- Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats 2023