Histopathological Changes in The Placentas of Pregnant Women with Premature Rupture of Membranes (PROM) and Preterm PROM

English (OpenAlex)

Introduction: Premature rupture of membranes (prom) and preterm prom (pprom) are critical obstetric complications associated with placental dysfunction. Histological changes in PPROM placentas have not been studied much in studies compared to PROM. This study aimed to investigates histopathological alterations in placental tissues of premature rupture of membranes of PROM and preterm PROM patients . Methods: This experimental non-randomized case-control study was conducted with 30 PROM patients , PPROM pregnant women and 30 healthy pregnant women at Dicle University Faculty of Medicine between May 2024 and May 2025. Placental tissues obtained following cesarean delivery were subjected to routine tissue monitoring. Placental samples were stained with hematoxylin-eosin and examined histopathologically using a light microscope. Results: When histopathological findings were compared between the PROM, PPROM and control groups, villous integrity in control groups, congestion in blood vessels, fibrinoid accumulation, inflammation and intervillous hemorrhage were higher in the PPROM group than in the control group (p<0.001).H&E revealed preserved villous integrity in controls, partial atrophy/fibrin deposition in PROM, and severe degeneration/edema in preterm PROM. Conclusion: Preterm PROM placentas display pronounced histopathological damage. The intricate relationship between PROM and placental pathology underscores the profound impact of metabolic changes on placental structure and function throughout pregnancy. Understanding these pathological changes is crucial for elucidating the progression of PPROM and its implications for maternal and fetal health, highlighting the importance of comprehensive placental analysis in managing pregnancies complicated by PROM. Keywords: Placenta, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Histopathology, Hematoxylin-Eosin Staining TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back