Article detail · 2022
Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research
- Year
- 2022
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue GigaScience
- Catalog match (ISSN) GigaScience
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, have been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution of toxin arsenals, such as how venom genes originate, how venom contributes to the fitness of venomous species, and which modifications at the genomic, transcriptomic, and protein level drive their evolution. These questions have received particularly little attention outside of snakes, cone snails, spiders, and scorpions. Venom compounds have further become a source of inspiration for translational research using their diverse bioactivities for various applications. We highlight here recent advances and new strategies in modern venomics and discuss how recent technological innovations and multi-omic methods dramatically improve research on venomous animals. The study of genomes and their modifications through CRISPR and knockdown technologies will increase our understanding of how toxins evolve and which functions they have in the different ontogenetic stages during the development of venomous animals. Mass spectrometry imaging combined with spatial transcriptomics, in situ hybridization techniques, and modern computer tomography gives us further insights into the spatial distribution of toxins in the venom system and the function of the venom apparatus. All these evolutionary and biological insights contribute to more efficiently identify venom compounds, which can then be synthesized or produced in adapted expression systems to test their bioactivity. Finally, we critically discuss recent agrochemical, pharmaceutical, therapeutic, and diagnostic (so-called translational) aspects of venoms from which humans benefit.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
144 citations
OpenAlex cited_by_count (cache / database)
15 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye 2024
- Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye 2024
- Web of venom: exploration of big data resources in animal toxin research 2024
- The biology and toxinology of blunt-nosed vipers 2025
- The biology and toxinology of blunt-nosed vipers 2025
- Individual Variation in Macrovipera lebetinus obtusa (Blunt-Nosed Viper) Venom from a Limited Area in Southeastern Anatolia (Türkiye) 2025
- Individual Variation in Macrovipera lebetinus obtusa (Blunt-Nosed Viper) Venom from a Limited Area in Southeastern Anatolia (Türkiye) 2025
- Individual variation in Macrovipera lebetinus obtusa (blunt-nosed viper) venom from a limited area in Southeastern Anatolia (Türkiye) 2025
- Biochemical characterization of Walterinnesia morgani (desert black cobra) venom (Serpentes: Elapidae) 2023
- Venomics and Peptidomics of Palearctic vipers: Clade-wide analysis of seven taxa of the genera Vipera , Montivipera , Macrovipera and Daboia across Türkiye 2024