Assessment of ELR, NLR, MPV, and CRP Levels in Patients With Acne Vulgaris

OpenAlex · English

BACKGROUND/AIMS:Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit.The relationship between some of the hematological parameters active in inflammation such as the neutrophil/lymphocyte ratio (NLR), the mean platelet volume (MPV), and C-reactive protein (CRP) has been demonstrated.In recent years, eosinophil cells have been shown to be associated with inflammation, and the eosinophil/lymphocyte ratio (ELR) has been shown to be an indicator of inflammation in some diseases.In this study, we aimed to evaluate the relationship between the ELR, NLR, MPV, and CRP levels, which are indicators of systemic inflammation, with acne severity parameters in patients with acne vulgaris. MATERIALS AND METHODS:A prospective study was planned with patients in our clinic who were diagnosed with acne vulgaris, who required routine blood parameters, and whose global acne score was calculated.The relationship between these parameters, which are an indicator of systemic inflammation and acne severity, was investigated. RESULTS:In our findings, MPV was found to be the strongest hematological marker for acne severity and inflammation.There was a significant difference between acne severity and ELR, and this difference was higher in the severe acne group. CONCLUSION:As far as we are aware, there has been no study on ELR levels in acne to date; this is the first study to evaluate this rate.Based on our findings, it is thought that ELR increases with the severity of acne and can be accepted as an indicator.In this context, we believe that there is a need for controlled studies involving the role of eosinophils in blood, tissue, and inflammation in the pathogenesis of acne.It is possible that the role of eosinophils in pathogenesis will explain itch-dominated acne patients and may also lead to the development of new targets for treatment.