Article detail · 2017
Action‐semantic and syntactic deficits in subjects at risk for Huntingtons disease
- Year
- 2017
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Neuropsychology
- Catalog match (ISSN) Journal of Neuropsychology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's disease, even during early disease stages. However, frontostriatal degeneration in these conditions may begin up to 15 years before the onset of clinical symptoms, opening avenues for pre-clinical detection via sensitive tasks. Such a mission is particularly critical in HD, given that patients' children have 50% chances of inheriting the disease. Against this background, we assessed whether deficits in the above-mentioned domains emerge in subjects at risk to develop HD. We administered tasks tapping action semantics, object semantics, and two forms of syntactic processing to 18 patients with HD, 19 asymptomatic first-degree relatives, and sociodemographically matched controls for each group. The patients evinced significant deficits in all tasks, but only those in the two target domains were independent of overall cognitive state. More crucially, relative to controls, the asymptomatic relatives were selectively impaired in action semantics and in the more complex syntactic task, with both patterns emerging irrespective of the subjects' overall cognitive state. Our findings highlight the relevance of these dysfunctions as potential prodromal biomarkers of HD. Moreover, they offer theoretical insights into the differential contributions of frontostriatal hubs to both domains while paving the way for innovations in diagnostic procedures.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
70 citations
OpenAlex cited_by_count (cache / database)
10 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson’s and Huntington’s disease 2017
- Parkinsons disease compromises the appraisal of action meanings evoked by naturalistic texts 2018
- Motor-system dynamics during naturalistic reading of action narratives in first and second language 2020
- Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy 2018
- When embodiment breaks down: Language deficits as novel avenues into movement disorders 2018
- Too late to be grounded? Motor resonance for action words acquired after middle childhood 2020
- A multidimensional and multi-feature framework for cardiac interoception 2020
- Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy 2021
- Action Semantics at the Bottom of the Brain: Insights From Dysplastic Cerebellar Gangliocytoma 2018
- An action-concept processing advantage in a patient with a double motor cortex 2022