Article detail · 2024
Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate
- Year
- 2024
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Frontiers in Pharmacology
- Catalog match (ISSN) Frontiers in Pharmacology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Introduction: The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer. Methods: In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles. Results: Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line. Discussion: We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site.
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Citations
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39 citations
OpenAlex cited_by_count (cache / database)
13 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Preparation and Characterization of Silver‐Loaded Magnetic Activated Carbon Produced from Crataegus Monogyna for Antimicrobial and Antioxidant Applications 2025
- Preparation and Characterization of Silver-Loaded Magnetic Activated Carbon Produced from Crataegus Monogyna for Antimicrobial and Antioxidant Applications 2025
- Preparation and Characterization of Silver‐Loaded Magnetic Activated Carbon Produced from Crataegus Monogyna for Antimicrobial and Antioxidant Applications 2025
- Preparation and Characterization of Silver‐Loaded Magnetic Activated Carbon Produced from Crataegus Monogyna for Antimicrobial and Antioxidant Applications 2025
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- pH-responsive magnetic cyclodextrin-liposome nanoplatforms for stabilization and targeted delivery of topotecan 2026