Article detail · 2009
Rituximab related viral infections in lymphoma patients
Journal
Leukemia & LymphomaISSN 1042-8194
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Leukemia & Lymphoma
- Catalog match (ISSN) Leukemia and Lymphoma
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Recently, a human/mouse chimeric monoclonal antibody, rituximab, has been successfully used to treat cases of B-cell non-Hodgkin's lymphoma and some autoimmune diseases. However, several viral infections related to rituximab have been reported in the literature, but were not well characterized. To further investigate this topic, relevant English language studies were identified through Medline. There were 64 previously reported cases of serious viral infection after rituximab treatment. The median age of the cases was 61 years (range: 21 - 79). The median time period from the start of rituximab treatment to viral infection diagnosis was 5.0 months (range: 1 - 20). The most frequently experienced viral infections were hepatitis B virus (HBV) (39.1%, n = 25), cytomegalovirus infection (CMV) (23.4%, n = 15), varicella-zoster virus (VZV) (9.4%, n = 6), and others (28.1%, n = 18). Of the patients with HBV infections, 13 (52.0%) died due to hepatic failure. Among the 39 cases that had viral infections other than HBV, 13 died due to these specific infections. In this study, about 50% of the rituximab-related HBV infections resulted in death, whereas this was the case in only 33% of the cases with other infections. Close monitoring for viral infection, particularly HBV and CMV, in patients treated with rituximab should be recommended.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
254 citations
OpenAlex cited_by_count (cache / database)
6 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Hepatitis C virus reactivation in cancer patients in the era of targeted therapies 2014
- Liver dysfunction after chemotherapy in lymphoma patients infected with hepatitis C 2008
- Evaluation and management of hepatitis B virus infection in hematopoietic stem cell transplantation: before and after transplantation 2011
- Rituximab Related Reversible Hepatocellular Damage 2012
- The Importance of CMV PCR Monitoring in Hematologic Malignant Patients Take Chemotherapy 2019
- The Importance of CMV PCR Monitoring in Hematologic Malignant Patients Take Chemotherapy 2019