Article detail · 2009
Use of Phosphatide Precursors to Promote Synaptogenesis
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Annual Review of Nutrition
- Catalog match (ISSN) Annual Review of Nutrition
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are depleted in Alzheimer's disease, as are some circulating compounds needed for synthesizing phosphatides, the major constituents of synaptic membranes. Animals given three of these compounds, all nutrients-uridine, the omega-3 polyunsaturated fatty acid docosahexaenoic acid, and choline-develop increased levels of brain phosphatides and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved cognition, and enhanced neurotransmitter release. The nutrients work by increasing the substrate-saturation of low-affinity enzymes that synthesize the phosphatides. Moreover, uridine and its nucleotide metabolites activate brain P2Y receptors, which control neuronal differentiation and synaptic protein synthesis. A preparation containing these compounds is being tested for treating Alzheimer's disease.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
133 citations
OpenAlex cited_by_count (cache / database)
22 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Nutritional approaches in the risk reduction and management of Alzheimer s disease 2013
- Nutritional modifiers of aging brain function use of uridine and other phosphatide precursors to increase formation of brain synapses 2010
- A specific multi nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats 2015
- A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats 2015
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic\u2013ischemic encephalopathy 2013
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic ischemic encephalopathy 2013
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic ischemic encephalopathy 2013
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic ischemic encephalopathy 2013
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic-ischemic encephalopathy 2013
- Neuroprotective effects of uridine in a rat model of neonatal hypoxic–ischemic encephalopathy 2013