Article detail · 2016
Protective effects of silymarin against acetaminophen induced hepatotoxicity and nephrotoxicity in mice
- Year
- 2016
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Toxicology and Industrial Health
- Catalog match (ISSN) Toxicology and Industrial Health
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
This study was designed to estimate protective effects of silymarin on acetaminophen (N-acetyl-p-aminophenol, paracetamol; APAP)-induced hepatotoxicity and nephrotoxicity in mice. Treatment of mice with overdose of APAP resulted in the elevation of aspartate aminotransferase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), and serum creatinine (SCr) levels in serum, liver, and kidney nitric oxide (NO) levels and significant histological changes including decreased body weight, swelling of hepatocytes, cell infiltration, dilatation and congestion, necrosis and apoptosis in liver, and dilatation of Bowman's capsular space and glomerular capillaries, pale-stained tubules epithelium, cell infiltration, and apoptosis in kidney. Posttreatment with silymarin 1 h after APAP injection for 7 days, however, significantly normalized the body weight, histological damage, serum ALT, AST, BUN, SCr, and tissue NO levels. Our observation suggested that silymarin ameliorated the toxic effects of APAP-induced hepatotoxicity and nephrotoxicity in mice. The protective role of silymarin against APAP-induced damages might result from its antioxidative and anti-inflammatory effects.
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Citations
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87 citations
OpenAlex cited_by_count (cache / database)
21 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats 2020
- Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats 2020
- Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats 2020
- Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats 2020
- Recent advances in two dimensional nanomaterial-based electrochemical (bio)sensing platforms for trace-level detection of amino acids and pharmaceuticals 2023
- Recent advances in two dimensional nanomaterial-based electrochemical (bio)sensing platforms for trace-level detection of amino acids and pharmaceuticals 2023
- Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model 2023