Article detail · 2018
A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives
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Abstract
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Abstract In this study, 1‐(4‐substitued benzyl)‐3,5‐diphenyl‐ 1H ‐1,2,4‐triazoles ( 2 a‐e ) and ethyl(3,5‐diphenyl‐ 1H ‐1,2,4‐triazole‐1‐yl)acetate ( 3 ) were synthesized starting from 3,5‐diphenyl‐ 1H ‐1,2,4‐triazole ( 1 ). The ethyl acetate derivative ( 3 ) was converted to 2‐(3,5‐diphenyl‐ 1H ‐1,2,4‐triazole‐1‐yl)acetohydrazide ( 4 ) in ethanolic medium with hydrazine hydrate. The reaction of the acetohydrazide ( 4 ) with suitable isothiocyanates generate 2‐[(3, 5‐diphenyl‐ 1H ‐1,2,4‐triazole‐1‐yl)acetyl]‐4‐methyl/phenyhlthiosemicarbazide ( 5 a,b ). The cyclization of the thiosemicarbazide ( 5 a,b ) in the presence of NaOH (2 M) resulted in the formation of 5‐[(3, 5‐diphenyl‐ 1H ‐1,2,4‐triazole‐1‐yl)methyl]‐4‐methyl/phenyl‐2,4‐dihidro‐3H‐1,2,4‐triazole‐3‐thiol ( 6 a,b ). Finally, the synthesized 1,2,4‐triazole‐3‐thiols ( 6 a,b ) were converted to their S‐ substituebenzyl derivatives ( 7 a‐j ). All of the synthesized compounds ( 1‐7 ) were also examined for antioxidant capacities, and antiurease and anti‐acetylcholinesterase (anti‐AChE) activities. It has been found that antioxidant capacity and anti‐urease activity of the compound 7 f is very good in biochemically active compounds.
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19 citations
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9 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Monoamine oxidase A and B inhibitory activities of 3,5-diphenyl-1,2,4-triazole substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives 2022
- Monoamine oxidase A and B inhibitory activities of 3,5-diphenyl-1,2,4-triazole substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives 2022
- Synthesis and kinetics studies of N ’xx-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazide derivatives as potent antidiabetic agents 2019
- Synthesis and kinetics studies of N ’xx-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazide derivatives as potent antidiabetic agents 2019
- Synthesis and kinetics studies of N′‐(2‐(3,5‐disubstituted‐4H‐1,2,4‐triazol‐4‐yl)acetyl)‐6/7/8‐substituted‐2‐oxo‐2H‐chromen‐3‐carbohydrazide derivatives as potent antidiabetic agents 2019
- Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5‐Diphenyl‐1H‐1,2,4‐Triazole Derivatives as Potential hEGFR Inhibitors 2025
- Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5‐Diphenyl‐1H‐1,2,4‐Triazole Derivatives as Potential hEGFR Inhibitors 2025
- Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5‐Diphenyl‐1H‐1,2,4‐Triazole Derivatives as Potential hEGFR Inhibitors 2025
- Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5‐Diphenyl‐1H‐1,2,4‐Triazole Derivatives as Potential hEGFR Inhibitors 2025