Effect of Urtica Dioica on bacterial translocation in mechanic icter model

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Sepsis and renal, hepatic and multi organ failure syndrome, due to bacterial translocation, if the operations were carried out for mechanic icter, still cause high morbidity and mortality.1 It is known that obstructions of the extra hepatic bile ducts increase the translocation of bacteria in the gastrointestinal system. It was reported that bacterial translocation causes sepsis and multiple organ failure syndrome.2 Urtica Dioica (UD) is a perennial plant with stinging hairs belonging to the plant family Urticaceae with a height of 30-100 cm. It is endemic in many parts of Turkey, and seeds have been widely used in folk medicine, particularly in advanced cancer patients, for a long time.3 In some studies, an anti proliferative effect in prostate cancer, an anti inflammatory effect in chronic inflammatory events such as rheumatoid arthritis, a mitogenic effect on the T lymphocytes, and an antidiuretic and hypotensive effect has been reported.4 It was also reported that UD prevents the toxic effect of carbon tetrachloride on the liver.3 The aim of the present study was to investigate the efficiency of UD on bacterial translocation in an experimental model. This investigation conformed to the ʻGuide for the